Graduate Biochemists Association

Department of Biochemistry and Molecular Biology, University of Dhaka

Profile of Dr. Abdul Khaleque

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Dr. Abdul Khaleque
Treasurer
Email: abdul.khaleque@northsouth.edu

About

Prof. Abdul Khaleque is a prominent Molecular Biologist and Biotechnologist with over a decade of experiences in basic research, teaching and industrial settings. He earned his Ph.D in Molecular Genetics from Kumamoto University, Japan and M.S in Biochemistry & Molecular Biology from Dhaka University, Bangladesh.

Abdul Khaleque has returned to Dhaka in 2007 after almost 10 years with the commitment and dedication to work in the area of Biotechnology and Bioscience. He is currently working at North South University as Director, Office of Admissions and Professor of Biochemistry in the Dept. of Biochemistry & Microbiology. Prior to his current position he served as the Chair of the same department for more than 5 years. Based on his service, quality of work, capability and dedication towards NSU, authority has given him the honor to be the Marshal for the 18th and 19th Convocation. He is doing all these extracurricular assignments in addition to his regular teaching and research.

Before joining to NSU, Dr. Abdul Khaleque has worked with Invitrogen Corp. California, USA, where he worked closely with Quality Assurance and Quality Control to identify potential areas of improvement as they pertain to regulatory or scientific issues. Prior to Invitrogen Corp., Abdul Khaleque worked in Boston University and Harvard Medical School, Massachusetts, USA. In both institutes he was actively involved in cancer research directed at understanding the role of heat shock proteins in cancer metastasis. He was also involved with various research projects at national and internationally recognized research organizations such as ICDDRB and BIRDEM. He is well acquainted with general molecular biology, molecular pathology and biochemistry techniques.

Over the past 19 years his research works have focused on many contemporary issues related to the cancer biology, mitochondrial protein transport and regulation of protein phosphorylation in signal transduction pathways and antioxidant contents of Bangladeshi fruits and vegetables. His research finding has been published in several international journals including Journal of Biological Chemistry, Oncogene, Journal of Immunology, Trends in Biochemical Sciences, Signal Transduction Insights etc. Recently in 2015, he published two book chapters in “Foodborne Pathogens and Food Safety” (CRC Press, Taylor & Francis Group, USA)

Abdul Khaleque also worked as a visiting researcher at La Trobe University, Melbourne, Australia (2002) and Kumamoto University, Kumamoto, Japan (1997). He has been awarded with several prestigious awards, including Oncology Fellowship (2005) from Harvard Medical School, Massachusetts, USA; Monbusho Scholarship (1997) from Ministry of Education and Science, Japan; Chancellor award from the President of the Peoples Republic of Bangladesh (1987).

Dr Khaleque possesses good communication, organizational, supervisory, research and teaching skills. In addition, he strives to be friendly and treat people with warmth and respect with his own interpersonal dealings.

Dr. Khaleque is happily married with two daughters and two sons. As a man he is self-driven and target oriented with a decent and simple life-style.

Selected
Publications

Research Articles:

  1. Ashish Kumar Majumder, Md. Abdul Khaleque, Kazi Nadim Hasan, Lamyah Sultana Meem, and Sharif Akhteruzzaman. Two cases of Klinefelter Syndrome Identified by Quantitative Fluorescence PCR (QF-PCR). Biores Comm. 1(1), 17-21 (2015)
  2. Sohidul Islam, Obaidur Rahman, Mahmud Hossain and Abdul Khaleque. Antioxidant Activity of Some Common Seasonal Fruits of Bangladesh. Biores Comm. 1(1), 28-31 (2015)
  3. Md. M. A. Khan, Narayan C. Paul, Md. A. Khaleque, Aniruddha Sarker, Md. T. Islam. Isolation and characterization of multifunctional phosphate solubilizing bacteria associated with rice (Oryza sativa L.) cultivated in Bangladesh. Submitted in ZNC (Zeitschrift für Naturforshung C- Journal of Bioscience). (2014)
  4. M Abdul Khaleque, Faisal Bin Rashed, Fannana Rafa, Gias Uddin Ahsan, Donald James Gomes. miRNA: An Overview of In Silico Prediction Method. Editorial. Bang J Med Sci. 18(2), 80-83 (2012)
  5. Kazi Nadim Hasan, Fahmida Nasrin, A Abu Taher, Sharif Neaz,  Sohidul Islam, Obaidur Rahman, Ishrat Jabeen, M Abdul Khaleque, Sharif Akhteruzzaman. Comparative Analysis of Hepatitis C Virus (HCV) RNA, Anti-HCV and Liver Transaminase Levels as Markers and Predictors of Infectivity in HCV Infection. Bang J Med Sci. 18(2), 120-125 (2012)
  6. Sohidul Islam, Lamyah Sultana Meem,  Kazi Nadim Hasan,  M Abdul Khaleque,  Obaidur Rahman. Multidrug Resistance of Pseudomonus aeruginosa Isolated from Burn Patients. Bang J Med Sci. 18(2), 132-134 (2012)
  7. Obaidur Rahman, Kazi Nadim Hasan, Abdul Khaleque, Ishrat Jabeen, Sohidul Islam. Dietary Intake of Urea from Puffed Rice (Muri) in Bangladesh. Bang J Med Sci. 18(1), 58-61 (2012)
  8. Ishtiaq Mahmud, Mousomi Akter, Nuruzzaman Masum, M A Khaleque, Zillur Rahman, Rowshan Ara Islam, M Sohrab Alam, Emran Kabir Chowdhury, Shahdat Hossain. Serum Homocysteine and its Association with Cardiovascular Disease (CVD). J Bang Soc Pharm Professionals. 1(II), 11-26 (2012)
  9. Md Abdul Khaleque, Ajit Bharti and Stuart K. Calderwood. Heregulin Induces Heal Shock Proteins in an HSF1 dependent Manner in cancer Cells and Leads to Protection from Apoptosis. In vivo. 25(3), 492-493 (2011)
  10. S. K. Calderwood, Y. Xie, X. Wang, M. A. Khaleque, S. D Chou, A. Murshid, T. Prince and Y. Zhang.  Signal Transduction Pathways Leading to Heat Shock Transcription. Signal Transduction Insights 2010:3 13-24 (2010)
  11. Ishtiaq Mahmud, Dilshat Sultana, Nuruzzaman Masum, Hussain M Shahjalal, Shamima Keka Islam, M A Khaleque, SAM Khairul Bashar. Lipid Profile in Thyroid Disorders and the Risk of Atherosclerotic Cardiovascular Diseases in the Middle-Aged Population of Bangladesh. Bang J Med Sci. 15(2), 87-92 (2009)
  12. Muhammad Maqsud Hossain, Fariza Shams, SAM Khairul Bashar, Md Abdul Khaleque, Nazmul Ahsan Khan, Kharirul Azam, Choudhury Rafiqul Ahsan, Donald James Gomes. Clinical aspects of Helicobacter pylori infection. Bang Med J. 14(2), 155-168 (2008).
  13. Md Abdul Khaleque, Ajit Bharti, Jianlin Gong, Philip J. Gray, Daniel R. Ciocca, Arturo Stati, Mariel Fanelli and Stuart K. Calderwood. Heat Shock Transcription Factor 1 Represses Transcription Through Association with Metastasis Associated Protein 1. Oncogene, 27(13):1886-93 (2008).
  14. Yutaka Enomoto, Ajit Bharti, Md Abdul Khaleque, Baizheng Song, Chunlei Liu, Vasso Apostolopoulos, Pei-xiang Xing, Stuart Calderwood and Jianlin Gong. Enhanced immunogenicity of heat shock protein 70 peptide complexes from dendritic cell-tumor fusion cells. J Immunol. 177: 5946-5955. (2006).
  15. Stuart K Calderwood, Md Abdul Khaleque, Douglas B. Sawyer and Daniel R. Ciocca. Heat shock proteins in cancer: chaperones of tumoregenesis. Review. Trends Biochem Sci.31(3):164-72. (2006)
  16. Md Abdul Khaleque, XiaoZhe Wang, Mei Juan Zhau, Rong Zhong, Matthias Gaestel and Stuart K Calderwood. Phosphorylation of HSF1 by MAPKAP Kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. J Biol Chem. 281(2):782-91. (2006). Equal contribution
  17. Md Abdul Khaleque, Ajit Bharti, Douglas Sawyer, Jianlin Gong, Ivor J. Benjamin, Mary Ann Stevenson and Stuart K. Calderwood. Induction of heat shock proteins by heregulin b1 leads to protection from apoptosis and anchorage-independent growth. Oncogene, 24, 6564-6573 (2005).
  18. Dan Tang, Md Abdul Khaleque, Ellen L. Jones, Jimmy R. Theriault, Cheng Li, Wing Hung Wong, Mary Ann Stevenson and Stuart K. Calderwood. Expression of heat shock proteins and HSP mRNA in human prostate carcinoma in vitro and in tumors. Cell Stress & Chaperones 10 (1), 46-58 (2005).
  19. Donghui Yu, Ehsan Khan, Md Abdul Khaleque, James Lee, Gary Laco, Glenda Kohlhagen, Surender Kharbanda, Yung-Chi Cheng, Yves Pommier and Ajit Bharti. Phosphorylation of DNA Topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity. J Biol Chem. 279(50):51851-61 (2004).
  20. Khaleque Md Abdul, Kazutoyo Terada, Tomomi Gotoh, Rahman Md. Hafizur, Masataka Mori. Characterization and functional analysis of a heart-enriched DnaJ/Hsp40 homolog dj4/DjA4. Cell Stress & Chaperones 7(2), 156-166 (2002).
  21. K Akhter, F Noor, MA Khaleque, N Rahman, S Shammy, T Mannan, N Kamal, JMA Hannan, L Ali. Acute effects of a low-calorie icecream on glycemic status and atherogenic risk factors of type 2 diabetic patients. Diabetes and Endocrine Journal 30(1), 14-16 (2002).
  22. Khaleque Md Abdul, Kazutoyo Terada, Masato Yano, Michael T. Ryan, Illo Streimann, Nicholas J. Hoogenraad, Masataka Mori. Functional analysis of human metaxin in mitochondrial protein import in cultured cells and its relationship with the Tom complex. Biochem Biophys Res Commun 276, 1028-1034 (2000).

Book Chapters:

  1. HSF1: An Emerging Factor in Cancer. Stuart Calderwood, Md Abdul Khaleque and Daniel R. Ciocca. In: Heat Shock Proteins in Cancer. Ed: Stuart K. Calderwood. Publisher: Springer (2007)
  2. Facts on Foodborne Pathogens. Abdul Khaleque and Md. Latiful Bari. In Foodborne Pathogens and Food Safety. Ed. Md Latiful Bari & Dike O. Ukuku. Publisher: CRC Press (Chapter 3, 2015)
  3. Impact of Changing Lifestyles and Consumer Demands on  Food Safety. Abdul Khaleque, Mohammad Mustafizur Rahman, Kazi Selim Anwar and Md. Nazim Uddin. In Foodborne Pathogens and Food Safety. Ed. Md Latiful Bari & Dike O. Ukuku. Publisher: CRC Press (Chapter 10, 2015)

Awards &
Honors

  • Research & Innovation Fund, Awarded from North South University, Dhaka, Bangladesh. (2012)
  • Travel Award from the Japan Neuroscience Society, Nagoya, Japan. (2009)
  • Oncology Fellowship, Harvard Medical School, Boston, MA (2005-2006)
  • Young Investigator Travel Award from Society for Thermal Medicine (2005)
  • Monbusho Scholarship from Ministry of Education and Science, Japan (1997-2002)
  • HDF scholarship under Talent Assistance Scheme, Bangladesh (1986-1994)
  • Begum Halima Khatun Scholarship from University of Dhaka, Bangladesh (1990)
  • Chancellor award from the President of the Peoples Republic of Bangladesh (1987)

Educational
Qualifications

Ph.D   in Molecular Genetics, Kumamoto University, Japan- 2002 Degree Awarded

M.S. in Biochemistry and Molecular Biology, University of Dhaka- 1994 (First Class)

B.S. in Biochemistry and Molecular Biology, University of Dhaka- 1992 (First Class)

HSC from Carmichael College, Rangpur (Rajshahi Board)- 1987 (First Division)

SSC from Rangpur Zilla School, Rangpur ((Rajshahi Board))- 1985 (First Division)

Academic
Experience

05/2015- present             Director, Office of Admissions and Professor, Dept. of Biology & Chemistry North South University

05/2014- 5/2015             Associate Professor & Chairman, Dept. of Biology & Chemistry, North South University, Dhaka.

01/2013- 04/2014           Associate Professor, Dept. of Biochemistry & Microbiology, North South University, Dhaka.

12/2011- 12/2012           Associate Professor & Chairman, Dept. of Biochemistry & Microbiology, North South University, Dhaka.

05/2009- 12/2011           Assistant Professor & Chairman, Dept. of Biochemistry & Microbiology, North South University, Dhaka.

08/2007- 04/2009           Assistant Professor, Dept. of Biochemistry & Microbiology, North South University, Dhaka

Teaching Genes and Diseases, Basic Biochemistry and Biotechnology, Biology I, Molecular Biology, Metabolism, Seminar, Laboratory courses and Biochemistry for MS Biotechnology, Proteins and Enzymes

12/2003-07/2006            Post-Doctoral Research Associate, Harvard Medical School, Boston, Massachusetts, USA

Worked in the Department of Radiation Oncology and completed several research projects on the role of heat shock proteins in cancer and published five full articles in journals like Treads in Biochemical Science, JBC, Oncogene, Journal of Immunology etc. Supervise the Research work & Thesis of several Masters Students.

Teaching: Basic Biochemistry and Molecular Biology

 

11/2002-11/2003            Post-Doctoral Research Associate, Boston University, Boston, Massachusetts, USA

Worked in the Department of Medicine (Stress Response Unit) and successfully completed the project “Expression of heat shock proteins and HSP mRNA in human prostate carcinoma in vitro and in tumors” which was published in JBC and Cell Stress and Chaperones.

Supervise the Research work & Thesis of several Students.

Teaching: Molecular Genetics, Biochemistry etc.

Corporate
Experience

07/2006-07/2007          Technical  Scientist, Zymed Division, Invitrogen Corporation, California, USA

Worked under Commercial Operation Department for the development of Cellular and Molecular Biology products such as pathology and research antibody, reagents etc. Conducted several lectures and training programs on cellular and molecular biology product development.

Industry experience

  • Establish and maintain Quality Systems consistent with GLP, GMP, FDA regulation and ISO requirements. Assures compliance to in-house and external specifications and standards.
  • Actively contribute to the data collection, trend analysis, investigation and improvements to processes, products and systems.  Manages the Corrective and Preventative Action (CAPA) system.
  • Work with QA personnel to ensure that appropriate scientific and regulatory improvements are properly introduced and phased into operations.
  • Design, evaluate, implement and maintain QA programs for product and process development, manufacturing and testing to ensure product quality and compliance with regulatory requirements.
  • Work with quality and operations to create and modify methods and procedures to ensure that appropriate processes are developed, tests are conducted.
  • Work with the Client and Program Managers to identify all study/regulatory requirements and effectively communicate these requirements to the Operational and Study Directors.
  • Responsible for providing pre- and post-sales technical support of Invitrogen cellular and molecular biology products to customers globally as well as relaying customer feedback to organization.
  • Interface with R&D to monitor new assay development and introduction. Participate in direction of R&D work, comment on new guidance documents.
  • Preparation of new and revised technical bulletins, expert reports, promotional brochures etc.
  • Lead and provide work direction to junior personnel.

Courses

Genes and Diseases, Basic Biochemistry and Biotechnology, Biology I, Molecular Biology I&II, Metabolism I&II, Seminar I&II, Laboratory courses and Biochemistry for MS Biotechnology

Membership and
Professional Activities

  • Editor, Bioresearch Communications, Bangladesh
  • Member, Cell Stress Society International, USA
  • Member, Society for Thermal Medicine, USA
  • Associate Member, American Association for Cancer Research, USA
  • Member, Global Network of Bangladeshi Biotechnologists, USA
  • Treasurer, Graduate Biochemists Association (GBA), Dhaka
  • EC Member, Bangladesh Society for Biochemistry and Molecular Biology, Bangladesh.
  • President, Talent Assistance Scheme Alumni Association (TASAA), Bangladesh
  • Life Member, American Alumni Association (AAA), Bangladesh
  • EC Member, Bangladesh Biosafety & Biosecurity Association (BBBA), Dhaka

Research Interests

Role of HSPs in Cancer Metastasis, Mitochondrial Protein Transport, Antioxident Content of Fruits & Vegetables

Profile of Dr. Abdul Khaleque